Heparin-induced thrombocytopenia: An Update
نویسندگان
چکیده
منابع مشابه
Heparin-induced thrombocytopenia: an update
Heparin-induced thrombocytopenia (HIT) is the most important and most frequent drug-induced, immune-mediated type of thrombocytopenia. It is associated with significant morbidity and mortality if unrecognized. In this review, we briefly discuss the main features of heparin-induced thrombocytopenia, particularly analyzing the most recent advances in the pathophysiology, diagnosis and treatment o...
متن کاملHeparin induced thrombocytopenia
Abstract Background and Objectives Heparin is still a commonly used anticoagulant in prophylaxis and treatment of thromboembolic events. Heparin-induced thrombocytopenia (HIT) is a life-threating adverse drug reaction of heparin. The diagnosis of HIT is made based on two important criteria, firstly clinical evaluation and secondly laboratory testing. In this comprehensive review, the authors w...
متن کاملHeparin-induced thrombocytopenia without thrombocytopenia in an intensive care unit.
[1] Lorette G, Jolly D, Ambrosi P, Dreyfuss D, Magne JL, Kohler C et al. Influence de la lecture critique d’articles sur les classements des étudiants aux épreuves classantes nationales 2009. Presse Med 2010;39(6):e118-25. [2] Giraudeau B, Maruani A. Correspondance à propos de l’article : Heparin-induced thrombocytopenia without thrombocytopenia in an intensive care unit « Influence de la lectu...
متن کاملHeparin-induced thrombocytopenia.
Heparin-induced thrombocytopenia (HIT) is an immune complication of heparin therapy caused by antibodies to complexes of platelet factor 4 (PF4) and heparin. Pathogenic antibodies to PF4/heparin bind and activate cellular FcγRIIA on platelets and monocytes to propagate a hypercoagulable state culminating in life-threatening thrombosis. It is now recognized that anti-PF4/heparin antibodies devel...
متن کاملHeparin induced thrombocytopenia
Heparin induced thrombocytopenia (HIT) is a prothrombotic syndrome initiated by platelet-activating auto-antibodies with potentially devastating complications. Once the diagnosis of HIT is suspected, discontinuation of heparin and treatment with an alternative anticoagulant are mandatory. While established drugs for HIT are no longer available, parenteral factor Xa inhibitors, thrombin inhibito...
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ژورنال
عنوان ژورنال: Cardiovascular Journal
سال: 1970
ISSN: 2309-6357,2071-0917
DOI: 10.3329/cardio.v3i2.9189